Rhabdomyolysis after Intentional Acetaminophen and Carbon Monoxide Poisoning

Acetaminophen is one of the most frequent causes of acute liverfailure. Rhabdomyolysis is a rare adverse reaction reported withthis drug. Carbon monoxide (CO) can also lead to muscle injury butonly after severe intoxication. We present a case of rhabdomyolysisassociated to Acetaminophen over dosage and mild carbon monoxideexposure. A 38-year-old man was admitted because of acute hepaticinjury due to voluntary acetaminophen overdose. He also reporteda mild carbon monoxide exposure. He showed a delayed rising ofserum creatinine with minimal elevation of other markers of renaldamage. Although he was asymptomatic, rhabdomyolysis wassuspected and confirmed by blood and urine analysis. The patientrecovered spontaneously with conservative management. This isthe first report of rhabdomyolysis associated with acetaminophenoverdose in which mild CO exposure could play a contributive role.