Are we ready for a medical ozone challenge?

Ozone therapy is gaining credence and is being used by an increasing number of clinicians to treat ever more diverse types of patients. Previous reviews have highlighted potential mechanisms-of-action arising out of clinical experience as well as theoretical bases of this therapy in various diseases. However, ozone therapy is still viewed with skepticism in mainstream medicine, especially since there has been scant evidence from stringent clinical trials. In this issue of the Journal of Experimental and Integrative Medicine, Re et al review the basic mechanisms underlying ozone therapy, and [J Exp Integr Med 2012; 2(3.000): 189-191]