Interaction of resveratrol analogues with biomembrane models:a calorimetric study on structural variations effects

Differential Scanning Calorimetry was used to study the interaction of new resveratrol derivatives usingdimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV) as biomembrane models. MLVprepared in the presence of increasing molar fractions of the following compounds: (A) 3,5,3’,5’-tetramethoxystilbene, (B) 3,5,3’,4’-tetramethoxystilbene, (C) 3,4,5,4’-tetramethoxystilbene, (D) 3,4,5,3’,5’-pentamethoxystilbene and (E) 3,4,2’,4’,5’-pentamethoxystilbene were analyzed to study the effects exerted bythe number and position of the substituents on the variations of thermotropic properties of the biomembranemodel. The results showed that the number and the position of the substituent strongly affected theinteraction between the compounds and the MLV based on DMPC. Kinetic experiments demonstrated that,the absorption of compounds A to E is limited in an aqueous medium. The presence of a lipophilic mediumimproves the absorption of the compounds by the biomembrane model.