Effect of vitamins C and E on reproductive system of male rats treated with sodium fluoride

The objective of the study was to investigate the effect of vitamin C administration (200 mg/ kg, orally) concomitantly withsodium fluoride (100 ppm in drinking water) for 60 days, the effect of vitamin E administration (500 mg / Kg diet) withsodium fluoride (100 ppm in drinking water) for 60 days and the effect of both vitamins in adult male rats. Sodium fluoridealone caused significant decrease in total sperms count, the percentage of the live sperms and epididymal head weightassociated with significant increase in the percentage of the sperm abnormalities compared with the control group.Administration of vitamin C with sodium fluoride and the two vitamins with sodium fluoride produced a significant increase intotal sperms count, the percentage of the live sperms and the relative weight of the epididymal head weight, accompanied witha significant decrease in the percentage of sperm abnormalities compared with sodium fluoride group. There were nosignificant changes in the total sperms count in vitamin E group. A significant increase in the percentage of the live sperms andthe epididymal head weight, and a significant decrease in the percentage of sperm abnormalities compared with sodiumfluoride group. It could be concluded that antioxidants administration (vitamin C or vitamin E and the interaction between vitamin E and C) concomitantly with sodium fluoride reduce the adverse effects caused by sodium fluoride on sexualefficiency of the adult male rats.