Intussusception in a term newborn with duct-dependent congenital heart disease

Prostaglandin E1 infusion is widely used to maintain patencyof ductus arteriosus in newborns with duct-dependentcongenital heart disease until surgery. ProstaglandinE1 is a lifesaving drug, but it has many side effects includingfever, apnea, bradycardia, hypotension, convulsion,edema, and cortical hyperostosis. The gastrointestinaltract has not been recognized as a major site of seriousadverse effects of prostaglandin E1 infusion, althoughdiarrhea is a well-recognized side effect that usually respondsto dose reduction. In this report, we present acase of intestinal intussusception presumably induced byprostaglandin therapy in a newborn with duct-dependentcongenital heart disease.Key words: Prostaglandin E1, newborn, gastrointestinal