The relationship between prognostic parameters and tumor associated tissue eosinophilia in supraglottic laryngeal tumors

Objective: Tumor-associated tissue eosinophilia (TATE)has been noted in human cancers, sometimes with differentresults regarding their association with clinical outcome.In this study, the association between TATE andprognostic parameters of supraglottic laryngeal cancerwas analyzed.Materials and methods: Sixty-two patients with diagnosisof supraglottic laryngeal squamous cell carcinoma andwho treated surgically in our center were evaluated. Thecases were divided into 3 categories according to the averagenumber of eosinophils per high-power field (400x):0 (negative), 1-5 (grade 1+), more than 5 (grade 2+).Results: We found 24 TATE-negative (38.7%) and 38TATE-positive (61.3%) cases. There was not any statisticallysignificant correlation between TATE and tumor differentiation,vascular invasion, perineural invasion, lymphnode metastasis, patients’ ages, T stages (p>0.05). Asexpected, vascular invasion correlated with lymph nodemetastasis (p=0.001).Conclusion: The results of this study showed that TATEhas no correlation with prognostic parameters such ashistologic differentiation, vascular invasion, perineuralinvasion, lymph node metastasis, patients’ ages and Tstages in supraglottic laryngeal squamous cell carcinoma.The data suggest that stromal eosinophilic infiltrationis not useful for determining biological aggressiveness insupraglottic laryngeal cancer.Key words: laryngeal carcinoma, supraglottic, eosinophilia,prognostic parameters