Aluminium Acetate: Role in Oxidative Metabolism of Albino Mice

Exposure to sublethal dose (3.5 mg kg-1) of aluminium acetate has revealed significant changes in LDH, ICDH, SDH and GDH in brain, liver and kidney of albino mice. These changes are highly significant in multiple dose treated individuals compared to single and double dose aluminium acetate administered mice. In order to understand the energy related alterations in glycolysis and Krebs cycle the activity levels of the selected dehydrogenases were estimated. The lactate dehydrogenase (LDH) activity showed increase in the tissues, where as succinic dehydrogenase (SDH) and isocitrate dehydrogenase (ICDH) were decreased in the tissues of aluminium acetate administered albino mice. The increased levels of LDH and decreased levels of SDH and ICDH confirms a shift in normal balance of glycolysis in favour of anaerobiasis. Glutamate dehydrogenase (GDH) activity was found to be elevated in all the tissues of aluminium acetate treated mice. The elevated GDH activity levels indicate its contribution to ammonia production and glutamate oxidation.