THE EFFECT OF RESVERATROL ON WEIGHT GAIN ASSOCIATED WITH OLANZAPINE TREATMENT

The use of antipsychotic medication has consistently been associated with serious side effects including weight gain and metabolic abnormalities. Strategies for mitigating these side effects have been tested, yet effective interventions have not been identified. Present study tested effect of resveratrol, a natural phytoalexin with on weight gain induced by the antipsychotic olanzapine. Male Sprague–Dawley rats fed a normal chow diet were randomized (n=6 per group) to receive one of the following for 18 days: vehicle plus vehicle, olanzapine plus vehicle (2.4 mg/kg, i.p.), olanzapine plus resveratrol (10 mg/kg, i.p.), Rats receiving olanzapine plus resveratrol (10 mg/kg i.p.), gained significantly less weight than rats receiving only olanzapine. Differences in weight gain were not attributable to decreased food intake.