STUDY ON EFFICACY OF ACARBOSE (WITH AND WITHOUT CORNSTARCH DIET) IN COMPARISON WITH ROSIGLITAZONE IN DIABETIC RATS

The aim of this study is to compare metabolic effects of acarbose and rosiglitazone, especially in controlling hyperglycemia and hypercholesterolemia. We have selected acarbose and rosiglitazone for the present study among various currently approved oral hypoglycemics. As diet is also an important component in diabetic therapy, effects of resistant starch diets (e.g. cooked cornstarch) on carbohydrate and lipid metabolism were also studied.The metabolic effects of the drugs were investigated and significant changes with respect to blood glucose levels, HbA1c along with lipids profile of drug-treated animals were compared with untreated animal after 7, 15 and 30 days. The experimental result showed excellent glycemic control when acarbose was administered alone. Acarbose along with cooked cornstarch diet produced a more favorable lipid profile, but with significant increased level (p<0.001) of triglycerides. These findings suggest that acarbose and acarbose along with cooked cornstarch are more effective in controlling hyperglycemia with more favorable lipid profile when compared with rosiglitazone.