Transient normoprolactinemic galactorrhea induced by fluoxetine

Hormonal side effects of antidepressants are infrequent.Galactorrhea is rarely reported among antidepressantrelated side effects. Antidepressants can directly stimulatepostsynaptic 5- Hydroxytryptamine (5-HT) receptorsin the hypothalamus or indirectly inhibit the tuberoinfundibulardopaminergic neurons through 5-HT, which mayincrease prolactin levels and later cause galactorrhea.However, galactorrhea may develop despite normal prolactinlevels during antidepressant treatment. We presenta case of normoprolactinemic galactorrhea in a woman,related with fluoxetine treatment. This report highlightsthe presence of unidentified mechanisms of selectiveserotonin reuptake inhibitor induced galactorrhea. J ClinExp Invest 2013; 4 (1): 105-106Key words: Fluoxetine, galactorrhea, side effect