Comparison of the efficacy of esmolol and lidocaine in the control of hemodynamic response associated with intubation: A randomized controlled trial

Objectives: The purpose of this randomized study is tocompare the effects of esmolol and lidocaine in the controlof hemodynamic response caused by endotrachealintubation.Methods: In this study, 40 patients with ASA I-II physicalstatus and between the ages of 19 and 76 were includedand randomly divided into two groups. In the Group E (n =20), iv bolus injection of 1.5 mg/kg esmolol, in the GroupL (n = 20), iv bolus injection of 1.5 mg/kg 2% lidocainewere given with iv bolus injection in 30 seconds. All patientsreceived the same anesthetic technique. Systolicblood pressure (SBP), diastolic blood pressure (DBP)and mean blood pressure (MBP) and heart rate measurementswere done at specified times and recorded. Recordswere assessed by an anesthesiologist blinded towhich drug is applied.Results: There was no difference between the groupsin demographic data (p>0.05). In both groups, with theimplementation of the study drug, systolic blood pressure,diastolic blood pressure and mean arterial blood pressuredecreased compared to controls, this reduction was lowerin Group E than Group L. In Group L, SBP values of 1.5and 7 minutes were higher than Group E (p <0.05). InGroup L, DBP and MBP values of 1.5 and 3.5 minuteswere higher than Group E (p <0.05).Conclusion: In conclusion, 1.5 mg/kg esmolol or 1.5 mg/kg lidocaine administered prior to induction were not superiorto each other regarding suppression of hemodynamicresponses to intubation. J Clin Exp Invest 2013; 4(1): 20-27Key words: Esmolol, lidocaine, intubation, hemodynamic response