Current perspectives on the efficacy and mechanisms of combination therapy for chronic hepatitis B virus

The antiviral therapy is a main method to control chronic hepatitis B and prevent cirrhosis and hepatocarcinoma. However，the efficacy of current antiviral drugs are unsatisfactory. In order to optimize the antiviral strategy, it is worthy to investigate an important choice to combine antiviral drugs of different antiviral mechanism or different antiviral drug resistances. Although some relative studies and evidences have been taken, there are still many problems and arguments about combination therapy, which needs deep understanding of the pathogenesis and mechanism of poor antiviral response.