Plerixafor (Mozobil) and other mobilizing agents

Peripheral blood stem cell (PBSC) collection has become the prevalent modality for the procurement of hematopoietic stem/precursor cells for autologous and allogeneic transplantation. The basic principles of PBSC collection from peripheral blood consist in the ability of chemotherapeutic agents and/or growth factors to mobilize these cells from bone marrow and in the capacity to concentrate them by modern and efficient blood cell separators...