The Effect of Periodontal Therapy on Serum CRP, IL-6 Levels and Periodontal Parameters in Patients Having Poorly and Well Controlled Type 2 Diabetes with Chronic Periodontitis: a 3-month evaluation

Aim: To evaluate the effect of nonsurgical periodontal therapy on serum C-reactive protein(CRP), interl kin-6 (IL-6) levels and periodontal parameters in patients with poorly and wellcontrolled type 2 diabetes with chronic periodontitis.Methods: Forty-five patients were included in the study. Of the 45, 30 had type 2 diabetesmellitus with chronic periodontitis (group 1A; poorly controlled group, n = 15, HbA1c ≥ 7%and group 1B; well controlled group, n = 15, HbA1c < 7%) and 15 were systemically healthy(group 2) with chronic periodontitis. Plaque index, gingival index, probing depth, clinicalattachment loss, gingival bleeding index scores, serum CRP and IL-6 concentrations weremeasured at baseline and 3 months after the nonsurgical periodontal therapy. Results: After the nonsurgical periodontal therapy all periodontal parameters and CRP and IL-6 levels decreased significantly by the third month compared to baseline values in all groups.No statistically significant difference was determined among the groups between baseline andthird-month periodontal parameters, or in CRP or IL-6 levels after nonsurgical periodontaltherapy. Conclusion: Improvement in periodontal health is effective on control of systemic infectionvia reducing serum concentrations of CRP and IL-6 in patients with poorly and well controlledtype 2 diabetes with chronic periodontitis. The effects of nonsurgical periodontal treatmentseems to be independent of the degree of diabetic status.