The Comparison α-Blocker+M3 Selective Anti-Muscarinic Combined Therapy And α-Blocker Monotherapy

Aim: Effectiveness and reliability comparison of alpha-blocker monotherapy (doksazosin) and combined alpha-blocker M3 selective antimuscarinic (doksazosin darifenacin) treatments on male patients with Benign prostate hyperplasia and accompanying OAB (overactive bladder) symptoms. Material and Method: 101 patients with ages 50 and above who had LUTS (Lower urinary tract symptoms) complaints were included in the study. Patients were randomly organized into two groups. One group had treatment with 4mg doksazosin, the other group had 4mg doksazosin combined with 7.5mg darifenacin. Patients were evaluated in accordance with BPH manuals of EUA (European Urology Association) and AUA (American Urology Association). Patients were re-evaluated on 12th week after the treatment. International prostate symptom scores (IPSS), IPSS quality of life scores (IPSS-QoL), maximum urine flow rate (Qmax), average urine flow rates (AFR) and PVR (Post Voiding Residual Volume) data were obtained before and after the treatment from all patients. Results: Patients who received combined treatment had experienced considerable drop (p