Renoprotective Effect of Terminalia Chebula on Gentamicin Induced Toxicity in Rats

An attempt was made to study the renoprotective effect of Terminalia chebula in a model of gentamicin induced toxicity in rats. Gentamicin was administered intraperitoneally at the dose of 80 mg/kg body weight once daily for seven days. Significant elevation of serum biochemical parameters like blood urea nitrogen (BUN), creatinine and gamma glutamyl transferase (GGT) occurred. Histopathological examination of kidney revealed acute tubular necrosis, protein inclusion and cast in the proximal tubules. Co-treatment with aqueous extract of Terminalia chebula significantly restored the renal hemodynamics. On histopathological evaluation, groups treated with Terminalia chebula showed restoration of kidney architecture towards normal. Thus the results of the present study suggest that Terminalia Chebula plant extract can be used as a protective agent in gentamicin induced renal toxicity.