Cassia Roxburghii Seed Galactomannan-A Potential Binding Agent in the Tablet Formulation

The present study involves isolation of gum from the seed of plant Cassia roxburghii by filteration and hot continuous percolation method then evaluated for its binding properties in the formulation of Paracetamol tablet containing 8%, 10% and 12% binding concentration. The binding properties of gum was evaluated in relation to conventional binder like guar gum, gelatin, Sod.CMC at different parameter like percentage of fines, tablet hardness, disintegration time, dissolution and friability and found that 8% binding concentration of both gum shows superior binding properties when compared to the other binders. Further study shows that increase in binding concentration of filtered and defatted C. roxburghii gum from 8% to 12%; decrease the percentage of fine, increase the hardness,increase the disintegration time, decrease the percentage of friability and decrease % cumulative release. The binder-excipients interaction study was also carried out by using FTIR i.e. by KBr pellet method which showed that C. roxburghii gum is compatible with drug and all excipients in the formulation. Results indicate that Paracetamol tablets prepared with 8 % of mucilage were found to be ideal for the preparation of uncoated tablet formulation.