Synthesis and Biological Evaluation of Novel Benzimidazole Derivative with Aspirin as Potent Antimicrobial & Antifungal Agents

Benzimidazole is a heterocyclic aromatic organic compound. It is an important pharmacophoreand a privileged structure in medicinal chemistry. This compound is bicyclic in nature which consistsof the fusion of benzene and imidazole. Nowadays is a moiety of choice which possesses manypharmacological properties. Benzimidazole and its derivatives have a long history as antimicrobialagents. Several thousands of benzimidazole analogs have been synthesized and screened forpharmacological activity. They are of wide interest because of their diverse biological activity andclinical applications. These heterocyclic systems have different activities as they can act asbacteriostats or bactericides, as well as fungicides and they are present in numerous antiparasitic,antitumoral and antiviral drugs. Also, some of them exhibit appreciable antiprotozoal activity. It wasshown that they have a moderate in vitro anti-HIV activity.In the present work, the novel Benzimidazole derivative was synthesized with Aspirin andevaluated for their antimicrobial & antifungal activities. The newly synthesized compound wassubjected to antibacterial activity against Staphylococcus aureus ATCC 250, Pseudomonas aeruginosaATCC 25619, Escherichia coli RSKK 313 & antifungal activity against Candida albicans RSKK 628.The antibacterial & antifungal activities were compared with the respective standard drugs. The MIC ofBenzimidazole derivative was found to be in the range 20-200 mg/ml on all the tested microorganisms.