Formulation and Evaluation of Fast Dissolving Tablets of Gliclazide

The objective of this research was to formulate fast dissolving tablet of gliclazide for rapid action. Direct compression method was adapted to prepare the fast dissolving tablets. All formulations are evaluated for post-compression parameters like hardness, disintegration time, weight variation, friability, wetting time, water absorption ratio and mouth feel. The mouth feel was done by taking human volunteers in a panel scale method. Different formulations were prepared using the superdisintegrants in three individual concentrations i.e. (3%, 5%, and 10%). The formulations for different concentrations were selected based on disintegration time, hardness and wetting time and were subjected to in-vitro dissolution studies. The results obtained showed that at 10% concentration superdisintegrants showed less d.t and good hardness. This might be due to high wicking and capillary action along with secondary burst effect of crosspovidone, and more gelling tendency and slow water uptake of tablet containing sodium starch glycolate and crosscarmellose sodium than crosspovidone. For formulation at 10% concentration the hardness was found to be 5 kg/cm2, 5.14 kg/cm2 and 4.2 kg/cm2 and disintegration was found to be about 6 seconds, 11.5 seconds and 8.9seconds. From these datas the formulation sd9 containing crospovidone at 10% was selected to be the best formulation.