Role of nitric oxide and reduced glutathione and their implication on typhoid

Typhoid one of the most important causes of illness and death, particularly among children and adolescents in south-central and Southeast Asia, due to poor sanitation and unsafe food and drinking water. Nitric oxide (NO) is a versatile molecules produced in a biological system. Reduced glutathione (GSH) is the most abundant cytosolic thiol that easily reacts with NO and forms S-nitrosoglutathione (GS-NO) these thiol compounds might decrease the levels of free forms of NO, thereby affecting its fate and biological activity. Infection with bacteria to control mice resulted in significant decrease in the GSH level by 10% at day 8 of infection and after treatment with formulated drugs significant increment was observed.