DESIGN AND DEVELOPMENT OF FAST DISSOLVING TABLETS CONTAINING ZIPRASIDONE BY DIRECT COMPRESSION METHOD

The aim of this study was to prepare fast disintegrating tablets of Ziprasidone by using various superdisintegrant. The tablets were prepared using mannitol as diluent and Kyron T-134 as taste masking agent along with three different levels of superdisintegrant. The superdisintegrant used in this study were Crosspovidone, Crosscarmelose sodium and Sodium starch glycolate. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, and disintegration time (DT) and dissolution study. Using the same excipients, the tablets were prepared by direct compression and were evaluated in the similar way. From the results obtained, it can be concluded that the tablet formulation prepared with 9% Crosspovidone showed Disintegration time of 12 seconds. Also the hardness, friability, dissolution rate (ZD3) were found to be acceptable according to standard limits.