EFFECT OF ANTHOCYANIN FRACTION ON CISPLATIN-INDUCED NEPHROTOXICITY

Present study was designed to evaluate the effect of anthocyanin fraction of Syzygium cumini on cisplatin-induced nephrotoxicity in male Albino rats. Anthocyanin fraction was administered by gastric intubation at two dose levels. Animals were divided into 5 groups. Group I animals received vehicle. On day 1, Group II animals received cisplatin (6 mg/kg, i,p., single dose). Group III (7.5mg/kg) and IV (15mg/kg) received anthocyanin fraction respectively at 1 hr before, 24 hr and 48 hr after cisplatin injection. Group V received only Anthocyanin fraction. After 72 hr of cisplatin injection, blood and urine were collected and estimated for serum markers level and creatinine clearance. Malonoaldehyde (MDA) levels and histological studies were also conducted. Cisplatin caused renal damage characterized by elevation of Blood Urine Nitrogen, Serum creatinine, Malonoaldehyde level with marked drop in Creatinine clearance, Anthocyanin fraction reversed all the effects induced by cisplatin in dose dependent manner. Histological studies also substantiated above mentioned results. Present study reveals that anthocyanin fraction attenuated the nephrotoxicity induced by cisplatin in rats.