Effect of Antibiotics on Pathophysiological Responses Induced in Mice Infected with Bordetella pertussis

This study was undertaken to evaluate and understand the effect of Augmentin, Erythromycin and Ofloxacin against Bordetella pertussis (B. pertussis) in murine model. Mice (BALB/C) were challenged with highly infective dose (2.2x109 CFU mL-1) of B. pertussis and relatedness of pathophysiological responses, its intensity and the course was studied by monitoring the infection with mouse weight gain, temperature, induction of leukocytosis and lung score. Treatment was started giving first dose orally after an hour of infection, therapy was continued for six days. Antibiotics appeared to have provided benefit in decreasing the infection. Conclusively, Augmentin was found more effective than Erythromycin and Ofloxacin and indicated more persistent and potent efficacy in vivo.