ANTIHYPERLIPIDEMIC EFFECT OF PANCHATIKTA GHANA AND SHUDDHA GUGGULU: AN EXPERIMENTAL STUDY

Hyperlipidemia is emerging as major health problem in the modern era. Hyperlipidemia leads to coronary artery disease, myocardial infarction and cerebrovascular accidents (CVA).Coronary heart disease (CHD) is the number one killer among the diseases and it accounts for 37% of adult deaths in the US every year. Nikolai Anichkov in 1912 discovered the role of cholesterol in CHD, currently the world’s most deadly disease. An experimental study was done on albino rats to evaluate the effect of Panchatikta Ghana (combination of Adhatoda vesica, Azadirachta indica, Tinospora cordifolia, Solanum xanthocarpum and Trichosanthes dioica) and Shuddha Guggulu (Commiphora mukul) in hyperlipidemia induced albino rats. The study showed that Shuddha Guggulu has cardioprotective activity as it has increased the HDL Level and this drug also reduced the serum triglycerides to significant level and thus gave antihypertriglyceridaemic activity too. Both of the drugs were free from any side effects. Shuddha Guggulu was having better effect in reducing the body weight of the albino rats than Panchatikta Ghana.