Effect of Aqueous Garlic (Ag) Extract on Aspirin Induced Gastric Mucosal Lesion in Albino Wistar Rats.

The aim of this study was to evaluate the effect of aqueous garlic (AG) extract on aspirin inducedgastric mucosal lesion. It was carried out on 72 albino Wistar rats. Animals were divided into two groups.Gastric ulcer group (n=36) and gastric secretion group (n=36). Each group was subdivided into control (n=16)and study groups (n=18). Control group was further subdivided into 3 subgroups including (1) Oral distilledwater subgroup (n=6); (2) Oral aspirin (150mg/kg) subgroup (n=6) and (3) Oral AG extract (150mg/kg)subgroup (n=6).The study group was also subdivided into (1) Oral aspirin (150mg/Kg) + AG extract(150mg/kg) subgroup(n=6); (2) Oral aspirin (150mg/Kg) + AG extract(300mg/kg) subgroup(n=6) and (3)Oralaspirin(150 mg/kg) + Cemitidine(50mg/kg) I.P subgroup((n=6).All groups were fasted for 36 hours beforepyloric ligation. Gastric secretions were collected, centrifuged and analysed.Gastric ulcer parameters were alsostudied for gastric ulcer group. There was significant decrease(p<0.05) of titratable acidity and total acid outputin aspirin(150mg/Kg) + AG (150mg/Kg) and aspirin(150mg/Kg) + AG (300mg/kg) when compared withaspirin(150mg/Kg) alone group. Also there was significant decrease (p<0.05) in ulcer index and ulcer scorein both groups than aspirin alone group. In comparison between garlic groups and cemitidine group there wasmore decrease in these parameters in cemitidine groups than garlic group. It seem s likely that AG extractoffered protective effects on aspirin induced gastric mucosal lesion.