Protective Effect of Cinnamomum tejpata on Lipid Peroxide Formation in Isolated Rat Liver Homogenate

Restrictions on the use of synthetic antioxidants are being imposed because of their toxic properties.The present study is the continuation of a program aimed at investigation on antioxidant activity of extractsfrom medicinal plants and to identify alternative natural and safe sources of food antioxidant especially fromplant origin. Free radicals are involved in more than 50 diseases. Day to day researchers are adding morenumber of diseases to the list. In this report the anti-peroxidative effect of alcoholic extract of Cinnamomumtejpata has been studied in rat liver homogenate. Ferrous sulphate has been used as inducer to induce lipid peroxidation. On the basis of results, it could be concluded that TBARS production in normal condition group isvery slow and in FeSO4 treated groups, it is very high. Initiation of lipid peroxidation by ferrous sulphate takesplace either through ferryl- perferryl com plex or through OH Radical from Fenton’s reaction. Effect of differentconcentrations of ferrous sulphate for induction of lipid peroxidation in rat liver homogenate was studied. Dosedependent increase in lipid peroxidation was found. Results revealed that at lower doses the rate of formationof TBARS is slow , which increased with dose. Significant and moderate results were found from 0.40 mM to0.80 mM of ferrous sulphate.