Regioselective one-pot, three component synthesis of ethyl 6-aryl-3-propylpyridazine-4-carboxylates in water

A regioselective synthesis of ethyl 6-aryl-3-propylpyridazine-4-carboxylates by one-pot three-component reaction of ethyl butyrylacetate with various arylglyoxals in the presence of hydrazine hydrate at room temperature in water was described.