DESIGN AND IN-VITRO EVALUATION OF MUCO- ADHESIVE BUCCAL TABLETS OF SALBUTAMOL SULPHATE

In the present investigation an attempt has been made to design efficacious and prolonged release mucoadhesive tablet of salbutamol sulphate using various polymers to avoid the first pass metabolism to reduce dossing frequency and to improve patient compliance. Mucoadhesive buccal tablet of salbutamol sulphate were fabricated with objective of avoiding first pass metabolism and to improve its bioavailability with reduction in dosing frequency. The mucoadhesive polymers used in the formulations were Carbopol 934P, Methocel K4M, and Chitosan. Tablets were prepared by direct compression method using polymers in different ratios. The formulations are characterised for swelling index, in-vitro bioadhesion strength and in-vitro release studies. The best mucoadgesieve performance and in-vitro drug release profile were exhibited by the tablet containing Chitosan and Methocel K4M in ratio of 1:1. It was observed that the optimised formulation follows Hixson Crowel release kinetics.