FORMULATION AND EVALUATION OF TETRACYCLINE HYDROCHLORIDE MICROCAPSULES BY SOLVENT EVAPORATION METHOD

In the present study microcapsules has been developed by using polymer ethyl cellulose by solvent evaporation method. Tetracyclin hydrochloride was chosen as model drug due to its bitter test and photosensitivity. Microcapsules are prepared by different ratio of thickness of coating layer and core. The prepared microcapsules were evaluated for its partical size, amount of drug entrapped and drug release pattern. The optimized formulation was stable, mask the bitter taste of tetracycline and also found to sustain release of drug as compared to conventional tablet.