Biochemical changes in experimental diabetes before and after treatment with mangifera indica and psidium guava extracts

Male adult albino rats were used to study the hypoglycemic effect of Mangifera indica and Psidium guajava aqueous extracts either used individually or in combination of as well as the effect of glibenclamide as reference sulfonylureas drug at the dose level of 0.5 mg/kg body weight in streptozotocin-diabetic rats. Preliminary test using different doses of each plant indicated that the most effective doses were 250 mg/kg body weight for each plant. Our studies was extended to include the effect of the tested doses on different biochemical parameters including serum insulin concentration, hepatic glycogen content, total proteins, total lipids and transaminases activities in serum and liver. The obtained data of the above mentioned investigations revealed great alleviation of the impaired glucose tolerance, serum insulin and hepatic glycogen content, also serum and hepatic total protein contents were increased as a result of treatment. In STZ-diabetic rats, the activities of (ALT, AST and ALP) either detected in sera or hepatic tissues were increased, then the activities were improved as a result of treatments.