Assessment of prenatal and perinatal characteristics of pregnants with gestationel diabetes mellitus who have postnatal glucose abnormalities

Purpose: To examine the difference in terms of prenatal and perinatal characteristics between gestational diabetic (GDM) cases diagnosed with impaired fasting glucose (IFG)and impaired glucose tolerance (IGT) during early postpartum period. Material and Methods: Cases who had no history of any glucose metabolism disorder and diagnosed as GDM due to American Diabetes Association (ADA) criteria were included. Subjects were inquired for pregestational characteristics(glucose abnormality in previous pregnancies, birth of macrosomic baby and history of diabetes in a first-degree relative), prenatal characteristics (age, body mass index BMI), features at diagnosis (BMI,weight-gain ,blood pressure and HbA1C), and perinatal characteristics (birth week and baby birth weight) were recorded. Oral glucose tolerance test (OGTT) was reperformed in the 6th postpartum week. Effects of pregestational, prenatal and perinatal features on postpartum glucose abnormalities were analysed. Results: Out of 80 cases who completed the study 58.7%(n=47) had normal glucose metabolism, 13.7%( n=11) had IFG and 27.5%(n=22) had IGT. No difference was found between pregestational, prenatal , perinatal characteristics, features at the time of diagnosis and postpartum OGTT results. Incidence of IFG in postpartum OGTT for those who had diabetes in a first degree relative was elevated when compared with other cases(p=0,042). The difference was preserved after adjustment for other characteristic features with multivariate analysis (p=0,037). Conclusion: Presence of diabetes in a first degree relative may be a risk factor for postnatal early IFG. In our study other pregestational, prenatal, perinatal factors and features at diagnosis didn t affect early postpartum glucose metabolism. [Cukurova Med J 2013; 38(4.000): 617-626]