IMMUNOHISTOCHEMICAL DETECTION OF ESTROGEN AND PROGESTERONE RECEPTORS OF HER-2/NEU RECEPTOR IN HUMAN MAMMARY CARCINOMA.

The present study was designed to evaluate the expression of estrogen and progesterone receptor as biomarkers in human benign and malignant mammary tumors. Tissue samples from tumors and adjacent uninvolved areas from fifteen breast cancer patients were analyzed. The expression of estrogen and progesterone receptors on frozen sections Her-2/neu receptor progression in breast cancer was determined immunohisto chemical. Incidence of receptor expression were significantly more among the cases with grade II malignancy (53.3 percent) than compared with grade I (6.6 percent) and grade III (40 percent) malignancy. Estrogens promote the development of mammary cancer and exert both direct and indirect proliferating effects.