SERUM UREA, CREATININE IN RELATION TO FASTING PLASMA GLUCOSE LEVELS IN TYPE 2 DIABETIC PATIENTS

India as a developing country has more prevelance of diabetes and now has more people with type 2 diabetes (more than 50 million) than any other nation. Diabetes mellitus is a chronic metabolic disorder that can lead to cardiovascular, renal, neurologic and retinal complications. Type 2 diabetes has quickly become a global health problem due to rapidly increasing population growth, aging, urbanization and increasing prevalence of obesity and physical inactivity. A total of 40 diabetic patients of both sexs aged between 35 to 75 years attending medicine OPD were included in the study.After obtaining informed consent from the study group 5 ml of fasting venous blood sample was collected. Plasma glucose was estimated by GOD – POD method. Estimation of plasma creatinine was done by the modified Jaffe’s method. Serum urea was estimated by Urease-Berthelot’s method. There was significant increase in levels of serum urea, creatinine and FPG (p<0.001) in diabetic patients compared to healthy controls. On applying Pearson’s correlation serum urea correlated positively with creatinine (p<0.001, r = 0.910) in cases and also in contorls (p<0.001, r = 0.868). Blood urea and creatinine is widely accepted to assess the renal functions. Good control of blood glucose level is absolute requirement to prevent progressive renal impairment.