SYNTHESIS, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF NEW BISISATIN MALONOHYDRAZIDES

N1,N3-bis(2-oxoindolin-3-ylidene)malonohydrazides (VIa-i) have been synthesized by the condensation of malonohydrazide (V) with corresponding isatin derivatives (III) in alcohol. The intermediate malonohydrazide (V) was prepared by the reaction of diethylamalonate (IV) with hydrazine hydrate. All the title compounds (VI) were screened for Acute toxicity, analgesic, anti-inflammatory and ulcerogenic activity. Ibuprofen and indomethacin were employed asstandard. The structures of newly synthesized compounds were established on the basis of elemental analysis, IR, 1H NMR and mass spectral data.