Soy Diet Diminish Oxidative Injure and Early Promotional Events Induced by CCl4 in Rat Liver

In this study, we have examines the impact of dietary soy on CCl4 induced oxidative stress, early tumor promoter markers and liver toxicity in male wistar rats. The dietary exposure mimics the repetitive nature of soy intake in human diets. Administration of soy flour (10 and 15% as diet) seven consecutive days as preventive intervention suppresses the lipidperoxidation (LPO), xanthine oxidase (XO) and release of serum toxicity marker enzymes viz., SGOT, LDH and SGPT significantly (p<0.001). Hepatic antioxidant status viz., reduced glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), quinone reductase (QR), catalase (CAT) was concomitantly restored in soy flour pre-treated groups (p<0.001). In addition, soy diet pre-treatment also prevented the CCl4 enhanced ornithine decarboxylase (ODC) and hepatic DNA synthesis significantly (p<0.001). In conclusion, Carbon tetrachloride-induced liver toxicity was markedly attenuated by soy flour pre-treatment and study gives some insight of mechanisms involved in diminution of free radical generating toxicants and enhancement of antioxidant armory, hence preventing further tissue damage, injury and hyper-proliferation.