UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF FINASTERIDE AND TAMSULOSIN IN COMBINED DOSAGE FORM

A specific, rapid and simple UV spectrophotometric method with good sensitivity was developed and validated for the simultaneous determination of finasteride and tamsulosin in standard solutions and tablets. In methanol, the λmax of finasteride and tamsulosin was found to be 219 and 224nm respectively. Using an Elico UV – Visible spectrophotometer (model SL – 159) with matched quartz cells, in this proposed method both these drugs obeyed linearity individually and in mixture with the concentration range of 12.5-62.5 μg/ml for finasteride and 1-5 μg/ml for tamsulosin with a correlation coefficient of 0.9981 and 0.9989. Assay results were in good agreement with label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.5974 and0.4096 with excellent precision and accuracy.