FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF LOCALLY ACTING H2-ANTAGONIST.

In the present work, floating gastroretentive formulation of Ranitidine HCl was formulated to sustained release of Ranitidine HCl above its site of absorption. To modulate the release characteristics,HPMC (K4M) and natural swelling agent Psyllum husk are used for single-unit floating matrix tablets by a direct compression technique. The floating approach was achieved by the use of Sodium bicarbonate.The prepared floating tablets were evaluated for their floating behavior, swelling studies, in-vitro drug release studies and kinetic analysis of the release data. The optimize formulation shows floating lag time within 3 min. The effect of HPMC (K4M) and swelling agent Psyllum husk on drug release was observed.Ranitidine HCl shows drug release till 12 hrs due to gel forming property of HPMC (K4M) and swelling capacity of Psyllum husk. Form the results, it can be conclude that the prepared gastroretentive tablet of Ranitidine HCl shows desirable release profile, good floating and sustained effect in stomach. The Fourier Transform Infra Red Spectroscopy studies revealed that there is no molecular interaction which may have implications on drug release haracteristics.