Antagonistic Activities of Lactic Acid Bacteria Isolated from Nigerian Fermented Dairy Food Against Organisms Implicated in Urinary Tract Infection

Five Lactic Acid Bacteria (LAB) were isolated from different indigenous fermented dairy foods and identified as Lactobacillus fermentum, L. brevis, L. plantarum, Lactococcus lactis and Streptococcus durans. The cell free supernatant of the selected LAB were able to inhibit the growth of all organisms implicated in urinary tract infection (UTI) used in this study. The largest zone of inhibition was produced by Lac. lactis K3 against Staphylococcus saprophyticus UCH 2051. The sensitivity of UTI pathogens to different antibiotics was investigated. The entire Gram-negative pathogens from UTI showed 100% resistance to Colistin, Augmentin, Nalidix acid, Nitrofuranton and Cotrimoxazole while most Gram positive pathogens from UTI were sensitive to different antibiotics used against them. The tested LAB produced various antimicrobial compounds such as organic acid, hydrogen peroxide and diacetyl. The highest yield of lactic acid (1.87 g L-1) was produced by Streptococcus durans K4 while the highest yield of diacetyl (2.324 g L-1) was produced by L. brevis M5 and the highest yield of hydrogen peroxide (0.00544 g L-1) was produced by L. plantarum N2.