IDENTIFICATION AND PREDICTION OF CORONARY HEART DISEASE IN PATIENTS WITH APOLIPOPROTEIN LEVELS

Coronary Heart Disease (CHD) is the leading cause of deaths in the developed and developing countries. CHD is always due to atherosclerosis. A number of risk factors have been reported for atherosclerosis. Of these, the major risk factors are high cholesterol level, hypertension, smoking and diabetes mellitus. Fifteen patients with coronary heart disease were chosen for the study. Blood samples were collected from the overnight fast CHD patients and the levels of lipid profile were analyzed and were compared to the age and sex matched normal persons. In the result, increased levels of cholesterol, triglycerides, VLDL-cholesterol, LDL-cholesterol and moderately elevated levels of HDL-cholesterol were seen. While in apoproteins, increased level of Apo-B and decreased level of Apo-A1 and lowered Apo-A1/Apo-B ratio were seen in CHD patients, when compared to the normal subjects. Increased cholesterol, LDL-cholesterol and decreased HDL cholesterol are considered to be high risk factor for CHD. These conventional lipid profiles were used to identify the CHD. The measurement of apolipoprotein-A1 and B may be more useful in the identification and prediction of CHD. Therefore, conclude that the quantization of apolipoproteins is superior to the traditional lipid profile in the identification and prediction of CHD.