HPTLC analysis and Anti-inflammatory activity of Jatropha gossypifolia L. root in mice and Wistar rats

: Jatropha gossypifolia has been used in Indian traditional system but there is paucity of scientific data on anti-inflammatory activity of root. Anti-inflammatory activity was evaluated by TPA (12-O-tetradecanoylphorbol-13-acetate) induced ear inflammation, carrageenan-induced paw edema and cotton pellet granuloma. Topical application of 0.5 and 1 mg extract significantly reduced the TPA induced ear inflammation. The extract (125 mg/kg p.o) significantly reduced the carrageenan induced edema. Seven days administration of 50 and 100 mg/kg of extract significantly reduced the cotton pellet granuloma. The activity might be due to effects on several mediators involving cyclooxygenase pathway resulting in prostaglandin formation and leukocyte migration.