FORMULATION AND EVALUATION OF SOLID DISPERSIONS OF GLIPIZIDE FOR DISSOLUTION RATE ENHANCEMENT

Glipizide is a class-II antidiabetic drug which is purely insoluble in water. Since only dissolved drug can pass the gastro intestinal membrane, proper solubility of the drug is ultimately desired. Solubility of the poorly soluble drug is enhanced by formulating solid dispersion using solvent evaporation method. Drug and carrier in different ratios like 1: 1, 1: 2, 1: 3 by keeping drug weight constant was considered for formulating solid dispersions. Then prepared solid dispersions were evaluated for their routine tests like Phase solubility, Invitro dissolutoion study and the results were observed and tabulated. FT-IR study was also done for drug, polymers and formulated solid dispersion having(1: 3) ratios of drug:carrier by KBr pellet method. From the study it was concluded that 1: 3 ratio of drug:carrier shows better phase solubility and invitro dissolution rate. Also it was confirmed from the FTIR Spectra that no extra peaks were observed indictes no interaction between drug and polymers in the formulated solid dispersions.