Synthesis of Di and Trisubstituted Oxazoles in Nonionic Liquid Under Catalyst Free Conditions

Catalyst free synthetic method was developed for di and tri substituted oxazoles from α -haloketones and urea/phenyl urea in Nonionic liquid like PEG 400.The reaction was carried out at ambient temperature and the product were obtained in excellent isolated yields (80-90%). Additionally, PEG could be recovered easily and was reused without evident loss in activity.