PREPARATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LORNOXICAM USING TAMARIND SEED POLYSACCHARIDE.

The main accusative of the present work was to develop sustained release matrix tablets of Lornoxicam for maintaining therapeutic blood or tissue levels of the drug for extended period of time with minimized local or systemic adverse effects. Tamarind Seed Polysaccharide (TSP) as a natural binder and it is source obtained from Tamarindus indica .The tablets were formulated by wet granulation method by using 10%, 20%, 30%, and 40% Tamarind Seed Polysaccharide (TSP) as a natural binding agent and its optimized batch was compared with maximum ratio of various binders (HPMC K4M, Sodium CMC, Guar Gum). Tablets with highest binder concentration showed maximum hardness (8.0 kg/cm2) and minimum friability (0.25%). After 24 hours tablets with 20% TSP binder showed maximum drug release (99.45%) and tablets with 40% TSP binder showed minimum drug release (62.55%). With increasing the percentage of natural polymer (TSP), release rate decreased, though drug release pattern was mainly dependent on the type of polymer. Among all the formulations, formulation LT - 2 which contain 20% TSP binder release the drug which follows Zero order kinetics via, swelling, diffusion and erosion. The FTIR study revealed that there was no chemical interaction between drug and excipients.