Comparative Study of Hepatoprotective Activity of Proprietary Polyherbal Preparations against Paracetamol Induced Toxicity

Despite the widespread use of polyherbal formulations, there is a lack of scientific evidence on their efficacy and safety. The present study was designed to evaluate the comparative hepatoprotective activity of three proprietary polyherbal formulations Liv-52, Livomyn and Livosin in acute liver toxicity in rat model induced by Paracetamol. Four groups of 6 albino wistar rats eachwere subjected to experimental study. Group 1 was given single dose of Paracetamol 500mg/kg orally on day 22, Group 2,3 and 4 were administered with 1.5 ml Liv-52, Livomyn and Livosin twice daily respectively for 21 days, then they were administered with Paracetamol single dose 500mg/kg orally on day 22. The hepatoprotective effect of these polyherbal preparations were evaluated by the assay of liver function biochemical parameters like Serum Glutamic Pyruvate Transaminase (SGPT), Alkaline Phosphatase (ALP) and Total Bilirubin (TB) levels. The results obtained have shown that the polyherbal hepatoprotective formulations Liv-52 and Livomyn were most effective at the dose of 0.15 ml/Rat. It was found that there was a significant decrease in the serum levels of SGPT, ALP and Total Bilirubin of Liv-52 and Livomyn whereas Livosin was found to be less effective, which justify their use as a hepatoprotective agent. The present study demonstrated that Liv 52 and Livomyn were more effective when compared to Livosin.