Evaluation of Antiepileptic Activity of Methanolic Extract of Celastrus paniculatus Willd Whole Plant in Rodents

The objective of the present study was to evaluate the antiepileptic activity of the methanolic extract of Celastrus paniculatus Willd. whole plant(MECP) using different in vivo experimental models. Epileptic seizure challenged animals treated with methanolic extract of Celastrus paniculatus Willd whole plant (MECP) at doses 200 mg/kg,400 mg/kg and 600 mg/kg showed reduction of Isoniazid (INH)- and Pentylenetetrazole (PTZ)- induced epileptic seizure. Onset of seizure was found to increase and the extension phase of seizure was found to be lowered in the extract treated animals as compared to control group. The methanolic extract of Celastrus paniculatus Willd. whole plant(MECP) significantly delayed the onset of epileptic seizure induced by INH and significantly reduced the duration(in sec) of tonic hind limb extension phase of PTZ-induced epileptic seizure. Thus the overall results suggest that the methanolic extract of Celastrus paniculatus Willd. whole plant(MECP) contains some active principles which may possess significant antiepileptic activity.