A MICROWAVE SYNTHESIS AND CHARACTERIZATION OF SOME QUINOLINE DERIVATIVES AND TESTED THEIR ANTIMICROBIAL ACTIVITY

In the present research work there are synthesis some quinoline derivations by using microwave techniques. The synthesis of 6- methoxy acetanilide (1) by reaction of 6-methoxy aniline with acetic anhydride under microwave irradiation. This acetanilide (2) treated withPOCl3 and DMF under microwave irradiation to form 2-chloro -3- formyl-6- methoxy quinoline (3). the synthesis of 2- chloro-6-methoxy 3- substituted amine by condensing with 2-chloro -3- formyl-6- methoxy quinoline(3) and substituted aromatic amine in presence of catalytic amount of glacial acetic acid under microwave irradiation and get final products(4) which displays valuable pharmaceutical activities such as antifungal, antibacterial, anticancer and anti inflammatory activities. The structural characterization of the synthesized compound by I R. and 1HNMR spectral data reported in table No 1.The synthesized quinoline derivatives were tested their antimicrobial activity with different strain of gram-positive and gram- negative bacteria and fungi the chloro and bromo moiety derivatives of the synthesized compounds show good activity against S-aurous and B-subtilis and nitro group containing compounds showed moderate activity against gram- negative stain of micro organisms.