13. Simultaneous HPLC-UV method for the estimation of artemether and lumefantrine in tablet dosage form

This paper describes the development and validation of a simultaneous HPLC-UV method for the estimation of artemether and lumefantrine in fixed-dose combination tablets. The method showed to be linear (r2 > 0.999), precise (RSD < 0.43%), accurate (recovery of 99.81% for artemether and 99.54% for lumefantrine), speci c and robust. Three batches of artemether and lumefantrine tablets were assayed by the validated method. The artemether contents in the tablets varied from 99.30 to 99.33%, while lumefantrine contents were 99.65 to 99.66%.