Eco-friendly Synthesis of Phthalimide Derivatives, their Analgesic Activity and QSAR Studies

Phthalimide derivatives syntheses were carried out by eco-friendly microwave irradiation methods where, montmorillonite-KSF was used as the reusable clay catalyst. In the context of green chemistry, among the non-conventional methods of reaction activation in organic synthesis, microwave irradiation for reaction activation provides an alternative to the conventional heating for introducing energy into chemical reactions by using the ability of some liquids and solids to transform electromagnetic energy into heat. These compounds were characterized by TLC, melting point determination, and by IR and 1H NMR spectroscopy. The acute oral toxicity studies of the compounds were carried out using OECD guidelines. The compounds were than screened for analgesic activity using Aspirin as the standard and activity was correlated with FISA (Hydrophilic component of the total accessible surface area). The molecular modeling software, Maestro, from Schrodinger, USA, was used for QSAR studies.