Chitosan Nanospheres As Potential Carrier Delivery of Pharmaceutical API’s

Chitosanis a biodegradable natural polymer. Chitosan nanospheres have gained more attention as drug delivery carriers becauseof their better stability, low toxicity, simple and mild preparation method, and providing versatile routes of administration. Chitosan nanospheres are used to provide controlled release of many drugs, improves the dissolution of poorly soluble drugs and to improve the bioavailability of degradable substances such as protein or enhance the uptake of hydrophilic substances across the epithelial layers.Their sub-micron size not only suitable for parenteral application, but also applicable for mucosal routes of administration, i.e., oral, nasal, and ocular mucosa, which are non-invasive route. This review is an insight into the exploitation of the various properties of chitosan to encapsulate drug. Various techniques used for preparing chitosan nanospheres and evaluation of these nanospheres and different categories of drug used as chitosan nanospheres have also been reviewed. Chitosan is a versatile polymer with wide applications range which is being used widely in marketed formulation potentially.