Synthesis and Evaluation of Biological Activities of Thiosemicarbazones Derivatives

A series of Thiosemicarbazones (A1, A2, A3, A4, A5, A6,A7) have been synthesized by treating thiosemicarbazide with different substituted aromatic aldehydes and then these compounds were further treated with acetic anhydrides to obtain acylated compounds (B1,B2,B3,B4,B5,B6 and D1,D2) respectively. The structures of the compounds were characterized on the basis of their IR and 1H-NMR data. All the synthesized compounds were evaluated for antibacterial, antifungal and locomotor activity.